Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Endocannabinoids Mediate Synaptic Plasticity At

30 Activation of Type 1 cannabinoid receptors (CB1R) in many central nervous system 31 structures induces both short and long term changes in synaptic transmission. Within 32 mammalian striatum, endocannabinoids (eCB) are one of several mechanisms that 33 induce synaptic plasticity at glutamatergic terminals onto medium spiny neurons. 34 Striatal synaptic plasticity may contribute a critical co...

متن کامل

Mu opioid receptors in the ventrolateral periaqueductal gray mediate stress-induced analgesia but not immobility in rat pups.

Rat pups become immobile and analgesic when exposed to an adult male rat. The aim of this study was to determine whether these reactions are under the control of endogenous opioids and to determine the role of the midbrain periaqueductal gray (PAG), which mediates stress-induced immobility and analgesia in adult animals. In Experiment 1, 14-day-old rats were injected systemically with the gener...

متن کامل

Nonopioid analgesia improves outcomes.

In Reply:—We thank Chelly et al. for their interest in our case report that described major ambulatory surgery with continuous regional anesthesia and a disposable infusion pump. Although we appreciate their comments, we believe the use of continuous local anesthetic infusions at home is an investigational area of pain control. As a result, despite their institutional bias, many of the issues t...

متن کامل

Amniotic fluid ingestion enhances opioid-mediated but not nonopioid-mediated analgesia.

Ingestion of amniotic fluid or placenta by rats has been shown to enhance several types of opioid-mediated analgesia: that induced by morphine, footshock, vaginal/cervical stimulation, and late pregnancy. This enhancement has also been blocked by administration of opioid antagonists. The present study was designed to examine further the specificity of the enhancement effect for opioid-mediated ...

متن کامل

Identification of a sex-specific quantitative trait locus mediating nonopioid stress-induced analgesia in female mice.

It is increasingly appreciated that the sexes differ in their perception of noxious stimuli and in their responsivity to exogenous and endogenous analgesic manipulations. We previously reported the existence of qualitative sex differences in the neurochemical mediation of nonopioid (i.e., naloxone-insensitive) stress-induced analgesia (SIA) produced by forced swims and suggested that female mic...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Neuropharmacology

سال: 2006

ISSN: 0028-3908

DOI: 10.1016/j.neuropharm.2005.10.007